Modulation of Pacemaker Potentials by Pyungwi-San in Interstitial Cells of Cajal from Murine Small Intestine - Pyungwi-San and Interstitial Cells of Cajal -
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منابع مشابه
Modulation of Pacemaker Potentials by Pyungwi-San in Interstitial Cells of Cajal from Murine Small Intestine
Pyungwi-san (PWS), a traditional herbal medicine, has been widely used for the treatment of gastrointestinal (GI) disorders such as inappetance, abdominal distension, borborygmus and diarrhea induced by gastric atony, gastric dilatation and GI catarrh [1, 2]. It is composed of Atractylodis Rhizoma (Atractylodes japonica), Citri Pericarpium (Citrus unshiu), Magnoliae Cortex (Machilus thunbergii)...
متن کاملModulation of pacemaker potentials by pyungwi-san in interstitial cells of cajal from murine small intestine: pyungwi-san and interstitial cells of cajal.
OBJECTIVE Pyungwi-san (PWS) plays a role in a number of physiologic and pharmacologic functions in many organs. Interstitial cells of Cajal (ICCs) are pacemaker cells that generate slow waves in the gastrointestinal (GI) tract. We aimed to investigate the beneficial effects of PWS in mouse small-intestinal ICCs. METHODS Enzymatic digestion was used to dissociate ICCs from the small intestine ...
متن کاملPacemaker potentials generated by interstitial cells of Cajal in the murine intestine.
Pacemaker potentials were recorded in situ from myenteric interstitial cells of Cajal (ICC-MY) in the murine small intestine. The nature of the two components of pacemaker potentials (upstroke and plateau) were investigated and compared with slow waves recorded from circular muscle cells. Pacemaker potentials and slow waves were not blocked by nifedipine (3 microM). In the presence of nifedipin...
متن کاملMenthol Modulates Pacemaker Potentials through TRPA1 Channels in Cultured Interstitial Cells of Cajal from Murine Small Intestine.
BACKGROUND/AIMS ICCs are the pacemaker cells responsible for slow waves in gastrointestinal (GI) smooth muscle, and generate periodic pacemaker potentials in current-clamp mode. METHODS The effects of menthol on the pacemaker potentials of cultured interstitial cells of Cajal (ICCs) from mouse small intestine were studied using the whole cell patch clamp technique. RESULTS Menthol (1 - 10 μ...
متن کاملEffects of ATP on Pacemaker Activity of Interstitial Cells of Cajal from the Mouse Small Intestine
Purinergic receptors play an important role in regulating gastrointestinal (GI) motility. Interstitial cells of Cajal (ICCs) are pacemaker cells that regulate GI smooth muscle activity. We studied the functional roles of external adenosine 5'-triphosphate (ATP) on pacemaker activity in cultured ICCs from mouse small intestines by using the whole-cell patch clamp technique and intracellular Ca2+...
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ژورنال
عنوان ژورنال: Journal of Pharmacopuncture
سال: 2013
ISSN: 2093-6966
DOI: 10.3831/kpi.2013.16.003